中文摘要：

Objective:To study the relationship between the single nucleotide polymorphisms(SNPs)of IFNGR2genes(rs9808753,rs11910627 and rs1532) and IL-12 B gene(rs2288831)and the susceptibility to hand,foot and mouth disease(HFMD)caused by enterovirus 71(EV71).Methods:Blood samples were collected from 145 HFMD children infected by EV71,104 children with EV71 covert infection,and 89 normal control children,followed by DNA extraction.IFNGR2 and IL-12 Bpolymorphisms were detected by imLDRTM.Results:Compared with the control group,IFNGR2rs9808753 genotype and allele distributions of EV71-infected group and EV71 covert infection group showed significant differences(P<0.05).A allele frequency in EV71-infected patients and covert EV71-infected patients was higher than that in the control group(P <0.05).While the genotype and allele frequencies of rs2288831 in IL-12 B did not show significant difference between EV71-infected groups and healthy controls.Conclusion:These findings suggested that the single nucleotide polymorphism of IFNGR2 gene site rs9808753(A/G)was associated with the susceptibility to EV71-infection,and A allele of rs9808753 might be one potential genetic susceptibility factor of EV71-infection.While the rs2288831(C/T)polymorphism of IL-12 Bdid not correlate with the susceptibility of EV71-infection.

英文摘要：

Objective：To study the relationship between the single nucleotide polymorphisms（SNPs）of IFNGR2genes（rs9808753,rs11910627 and rs1532） and IL-12 B gene（rs2288831）and the susceptibility to hand,foot and mouth disease（HFMD）caused by enterovirus 71（EV71）.Methods：Blood samples were collected from 145 HFMD children infected by EV71,104 children with EV71 covert infection,and 89 normal control children,followed by DNA extraction.IFNGR2 and IL-12 Bpolymorphisms were detected by imLDRTM.Results：Compared with the control group,IFNGR2rs9808753 genotype and allele distributions of EV71-infected group and EV71 covert infection group showed significant differences（P〈0.05）.A allele frequency in EV71-infected patients and covert EV71-infected patients was higher than that in the control group（P〈 0.05）.While the genotype and allele frequencies of rs2288831 in IL-12 B did not show significant difference between EV71-infected groups and healthy controls.Conclusion：These findings suggested that the single nucleotide polymorphism of IFNGR2 gene site rs9808753（A/G）was associated with the susceptibility to EV71-infection,and A allele of rs9808753 might be one potential genetic susceptibility factor of EV71-infection.While the rs2288831（C/T）polymorphism of IL-12 Bdid not correlate with the susceptibility of EV71-infection.