中文摘要：

连接肝炎 B 病毒(HBV ) 和丙肝病毒(HCV ) 感染到 hepatocellular 癌(HCC ) 的机制仍然保持大部分未知。生来的杀手(NK ) 房间说明肝淋巴细胞的全部的数字的 25%-50% ，建议 NK 房间起在肝免疫的一个重要作用。在血和 HCC 病人的肿瘤纸巾的 NK 房间的数字断然与他们的幸存和预后被相关。而且，在 HCC 纸巾的一组 NK 联系房间的基因断然与延长幸存被联系。这些事实建议 NK 房间和 HCC 前进强烈被联系。在这评论，我们与长期的 HBV 和 HCV 感染在病人描述反常 NK 房间和他们的功能的缺陷，它贡献 HCC 的前进。然后，我们在 HCC 病人在血和肝 NK 房间的数字和显型基于畸形与 HCC 总结 NK 房间的协会。特别地，代表更低的 cytotoxicity 和损害 cytokine 生产的 NK 房间的疲劳可以为 HCC 的出现用作一个预言者。最后，我们在场在在肝癌症的鼠标模型并且在临床的试用进行的 NK 房间免疫疗法的当前的成就，加亮 chemoimmunotherapy， NK 房间转移，基因治疗， cytokine 治疗和 mAb 治疗怎么在 HCC 治疗改进 NK 房间功能。它是想得到的治疗学的策略将独自或在有另外的治疗的联合是的那 NK 基于房间的 anti-HCC 为 HCC 治疗的大诺言。

英文摘要：

The mechanisms linking hepatitis B virus （HBV） and hepatitis C virus （HCV） infection to hepatocellular carcinoma （HCC） remain largely unknown. Natural killer （NK） cells account for 25%–50% of the total number of liver lymphocytes, suggesting that NK cells play an important role in liver immunity. The number of NK cells in the blood and tumor tissues of HCC patients is positively correlated with their survival and prognosis. Furthermore, a group of NK cell-associated genes in HCC tissues is positively associated with the prolonged survival. These facts suggest that NK cells and HCC progression are strongly associated. In this review, we describe the abnormal NK cells and their functional impairment in patients with chronic HBV and HCV infection, which contribute to the progression of HCC. Then, we summarize the association of NK cells with HCC based on the abnormalities in the numbers and phenotypes of blood and liver NK cells in HCC patients. In particular, the exhaustion of NK cells that represents lower cytotoxicity and impaired cytokine production may serve as a predictor for the occurrence of HCC. Finally, we present the current achievements in NK cell immunotherapy conducted in mouse models of liver cancer and in clinical trials, highlighting how chemoimmunotherapy, NK cell transfer, gene therapy, cytokine therapy and mAb therapy improve NK cell function in HCC treatment. It is conceivable that NK cell-based anti-HCC therapeutic strategies alone or in combination with other therapies will be great promise for HCC treatment.