中文摘要：

有关血管源性因素对阿尔茨海默病（Alzheimer’s disease,AD）影响的讨论由来已久。传统的分类将老年痴呆（vascular dementia,VaD）划分为血管性痴呆以及阿尔茨海默病。然而,近年来的研究发现,心血管疾病与AD具有共同的危险因素,包括易感基因、脂代谢紊乱和高胱氨酸血症等。血管损伤因素诱导痴呆的发生,同时伴有AD样的病理改变,这些因素包括动脉粥样硬化、高血压、糖尿病和脑卒中等。此外,罹患AD又可产生或加重血管病变。重提＂血管假说＂的意义在于多视角地探讨其本质,并为AD的诊断和治疗方式提供不同视角。本文重点综述了近年来有关AD的研究进展,列举了AD＂血管假说＂的可能依据,并提出新的思考。

英文摘要：

It has been debated for a long time whether the vascular factors are involved in the pathoprogression of Alzheimer＇s disease（AD）.Traditionally,senile dementia was classified into vascular dementia and AD.However,more and more evidences have shown that both cardiovascular disease（CVD） and AD share similar risk factors,such as predisposing genes,lipoidosis and homocystinemia.Risk factors of vascular lesions,artherosclerosis,hypertension,diabetes and cerebral stroke,generally can accelerate the progression of AD.On the other hand,the patients with AD show progressively cardiovascular problem or deteriorate clinic manifestation of CVD.Therefore,in this review,we mainly summarized recent publication regarding the relationship between vascular dementia and AD.We would further discuss ＂vascular hypothesis＂ that might be an important cause for the development of AD.