中文摘要：

基质辅助激光解吸电离质谱（MAI，DIMS）用于分析组织切片已成为质谱学的一个新领域。质谱成像技术通过直接对组织切片表面的质谱扫描，可以快速直观地分析组织中的分子，如蛋白质、多肽、药物分子、代谢产物等及其空间分布信息。本工作综述了组织切片的质谱成像原理，方法学和相关应用。

英文摘要：

Matrix assisted laser desorption ionization mass spectrometry （MALD MS） for tissue section analysis is a new area in mass spectrometry. Profiling and imaging molecules directly from thin tissue sections by MALDI MS permit sensitive and rapid analysis of compounds including proteins, peptides, drug and metabolic product as well as afford their spatial distribution. This paper reviews the principle of profiling and imaging mass spectrometry, methodology and recent applications.