中文摘要：

肿瘤干细胞（CSC）在肿瘤血管生成中有重要作用，血管生成因子、乏氧等介导了这一过程。CSC能分化成血管内皮细胞，并且参与血管生成拟态的形成，这可能是肿瘤启动和进展的关键因素之一。深入研究CSC在肿瘤血管生成中的作用对肿瘤的靶向治疗有重大意义。

英文摘要：

Cancer stem cells （CSC） play a crucial role in the tumor angiogenesis. Angiogenic factors and hypoxia mediate the process. CSC can differentiate into vascular endothelial cells and participate in the for- mation of vasculogenic mimicry, which may be one of the key factors in the initiation and progression of tumors. Indepth studies of the roles of CSC in tumor angiogenesis might help provide the basis for developing more effec- tive therapeutic drug targets.