中文摘要：

不否则在中央神经系统以内检测了， Interleukin-13 受体 alpha2 (IL-13Ralpha2 ) 是 glioma-restrictedcell-surface epitope。现在的学习是与 IL-13Ralpha2-specific 细胞毒素的 Tlymphocyte (CTL ) 指向恶意的 glioma 的途径与人的白血球由多重刺激从外部血导致了健康施主的单音的原子房间的一篇小说的一份报告抗原(HLA )-A2-restricted IL-13Ralpha2_(345-353 ) peptide-pulsedT2 房间。导致的 CTL 证明对 T2 房间的特定的细胞溶解与表示 IL-13Ralpha2_(345-353 ) 的肽和 HLA-A2+glioma 房间搏动了，当 expressIL-13Ralpha2_(345-353 ) 不能被 CTL.The 肽特定的活动认出的 HLA-A2 glioma 房间线被禁止时 byanti-HLA 一级单音的同种细胞的抗体。这些结果建议导致的 CTL 特定的 forIL-13Ralpha2_(345-353 ) 肽能是为有恶意的 glioma 的 HLA-A2patients 的特定的免疫疗法的一个潜在的目标。

英文摘要：

Interleukin-13 receptor α2 （IL-13Rα2） is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system. The present study is a report of a novel approach of targeting malignant glioma with IL-1 3Rα2-specific cytotoxic T lymphocyte （CTL） induced from the peripheral blood mononuclear cells of healthy donors by multiple stimulations with human leukocyte antigen （HLA）-A2-restricted IL-1 3Rα2345-353 peptide-pulsed T2 cells. The induced CTL showed specific lysis against T2 cells pulsed with the peptide and HLA-A2^＋ glioma cells expressing IL- 1 3Rα2345-353, while HLA-A2 glioma cell lines that express IL-13Rα2345-353 could not be recognized by CTL. The peptide-specific activity was inhibited by anti-HLA class I monoclonal antibody. These results suggest that the induced CTL specific for IL-1 3Rα2345-353 peptide could be a potential target of specific immunotherapy for HLA-A2 patients with malignant glioma.