目的探讨三酰甘油(TG)对16项常见临床生化检测结果的干扰剂量效应。方法参照美国临床和实验室标准化协会《临床化学干扰试验-批准指南》(EP7-A2)要求进行干扰试验,确定干扰物TG与干扰效果(偏差)之间的剂量效应。结果 TG对总蛋白、清蛋白、葡萄糖、尿素、碱性磷酸酶、镁、无机磷、钙、血清丙氨酸氨基转移酶、门冬氨酸氨基转移酶、铁存在正向干扰,其中前8项回归方程线性关系显著(P〈0.05),后3项回归方程二次项关系显著(P〈0.05)。对γ-谷氨酰转肽酶、肌酸激酶、乳酸脱氢酶、肌酐、尿酸存在负向干扰,回归方程线性关系显著(P〈0.05)。结论 TG对临床常见生化检测结果存在不同剂量效应的干扰。
Objective To explore the dose response of triglycerides(TG)on 16 common biochemical examination results.Methods According to the clinical and laboratory standards institute EP7-A2 file to conducted interference test,determine the dose response between distractors(triglycerides)and interference effect(deviation).Results TG had positive interference on total protein,albumin,glucose,urea,alkaline phosphatase,magnalium,phosphorus,calcium,alamine aminotransferase,aspartic aminotransferase and iron.And the first eight were significant entered the linear regression equation(P〈0.05),and the latter three quadratic regression equation were significant(P〈0.05).The interference of TG on glutamyltranspeptidase,creatine kinase,lactic dehydrogenase,creatinine and uric acid were negative,and the linear regression equation were significant(P〈0.05).Conclusion There might be different dose response of TG on common biochemical examination indicators.