中文摘要：

桑（Morus alba L．）为桑科（Moraceae）桑属（Morus）落叶乔木，其叶、枝、根（皮）和果均为中国传统中药。桑的药理活性成分主要包括黄酮类、生物碱类、甾类及香豆素类化合物等，具有降血糖、降血脂、降血压、抗氧化、抗炎、抗菌、抗肿瘤和免疫调节等药理活性。本文对桑及其主要成分的药理活性、药代动力学以及基于细胞色素P450和转运蛋白的药物相互作用进行综述。

英文摘要：

Morus alba L. （mulberry） is a well-known deciduous tree, belonging to the genus of Morus of Moraceae famlily. Its leaves, twigs, roots （bark） and fruits are widely used in the traditional Chinese medicine. The active constituents of mulberry contained flavonoids, alkaloids, steroids, coumarins, with the significant hypoglycemic, hypolipidemic, antihypertension, anti-oxidation, anti-inflammatory, anti-bacterial, anti-tumor and immunomodulatory activities. This review summarized the research progress of the major pharmacological activity, pharmacokinetics and drug-drug interaction based on CYPs and transporters of mulberry and its active constituents.