中文摘要：

肿瘤多药耐药（MDR）是化疗失败的重要原因,无机纳米粒因其独特的结构及组成特点,使之具有高稳定性、大表面积、较多的无机材料选择、丰富的理化功能以及独特的生物学行为,因此较传统有机材料纳米粒更优的克服MDR效果。笔者拟通过检索国内外相关文献,整理无机纳米粒克服肿瘤MDR的相关特点、分析可能机制,并着重介绍采用纳米技术制备介孔二氧化硅纳米粒、金纳米粒、二氧化钛纳米粒、磁性四氧化三铁纳米粒、银纳米粒及联合其他手段等无机纳米粒克服MDR的研究进展,并对后续研究提出建议。

英文摘要：

Multidrug resistance （MDR） is one of the major obstacles for successful chemotherapy in cancer. Inorganic material- based nanoparticles provide a novel choice to effectively circumvent the intrinsic drawbacks of traditional organic materials in overco- ming the multidrug resistance （MDR） of cancer cells due to their unique structural and compositional characteristics, for example, high stability, large surface area, tunable compositions, abundant physicochemical multifunctionalities, and specific biological behaviors. In this work, the recent advances of inorganic materials-based nanoparticles to overcome MDR of cancer ceils were reviewed. And the advantage and mechanism of inorganic materials-based nanoparticles to overcome MDR were summarized. The recent development of inorganic materials-based nanoparticles （ mesoporous SiO2, Au, TiO2, magnetic Fe3O4, Ag, combinations of inorganic materials- based nanoparticles with traditional overcoming MDR strategy etc. ） , to overcome the MDR were also discussed. And the future developments of these inorganic materials-based nanoparticles are suggested. These elaborately designed inorganic materials-based nanoparticles offer an unprecedented opportunity and show the encouraging bright future for overcoming the MDR of tumors.