中文摘要：

采用内酯开环聚合法合成了聚乙二醇-b-聚（L-乳酸）（1）和聚乙二醇-b-聚（α-羟基辛酸）（2）,将1和2一起溶解在二氯甲烷中为油相,以盐酸阿霉素（3）水溶液为内水相,用超声分散法形成油包水（W/O）乳液后静电纺丝,形成外壳为[1＋2],内芯包裹有3的纤维毡。扫描电子显微镜和广角X-射线扫描分析未发现纤维表面析出3结晶。纤维毡的酶降解药物释放研究结果表明,2的添加不仅未明显改变3的释放行为,而且可改善纤维对酶降解的耐受性。3的释放行为经Weibull模型和Highchi模型拟合,回归系数较高。

英文摘要：

Polyethylene glycol-b-poly（L-lactic acid）（1）and polyethylene glycol-b-poly（α-hydroxy-octanoic acid）（2）was synthesized by ring opening polymerization.1 and 2 was mixed in CH2Cl2 forming oil phase and ultra-sonicated with doxorubicin HCl water solution to form water in oil（W/O）emulsion.The W/O emulsion was immediately electrospun to form fibrofelts with hybrid polymer shell and drug core structure.By scanning electronic microscope observation and wide angle X-ray diffraction detection,drug crystal was not found on the fibers.Drug release experiment under enzyme degradartion indicated that addition of 2 did not change the release behavior of fibers and made the fibers resisted to enzyme degradation.Drug release behavior obeyed Weibull model and Highchi model after regression.