中文摘要：

目的 观察不同病因类型脑梗死患者急性期血浆同型半胱氨酸水平,探讨其与CISS分型的关系.方法 测定在我院神经内科住院的发病72小时内的308例脑梗死患者及300例健康对照者血浆同型半胱氨酸水平,按CISS分型将脑梗死患者分为大动脉粥样硬化性脑梗死（LAA）组、心源性脑梗死（CE）组、穿支动脉闭塞性脑梗死（PAO）组、其他病因明确性脑梗死（OC）组和不明病因性脑梗死（UND）组,并进行统计学分析.结果 脑梗死患者血浆同型半胱氨酸水平高于对照组（P＜0.05）;LAA及PAO组同型半胱氨酸水平明显高于对照组（P＜0.05）,其余各组同型半胱氨酸水平与对照组差异无统计学意义（P＞0.05）.结论 同型半胱氨酸水平增高可能是LAA、PAO亚型脑梗死的危险因素,且同型半胱氨酸水平对CISS分型的提示具有一定的临床意义.

英文摘要：

Objective To explore the correlation of plasma homocysteine and Chinese ischemic stroke subclassifi- cation in patients with acute cerebral infarction. Methods 308 patients with acute cerebral infarction and 300 healthy controls were included in this study, all stroke patients were divided into large artery atherosclerosis（LAA）, Cardiogenic stroke, perforating branch arterial occlusion, other clarity diseases, Undetermined etiology according to the CISS crite- ria. Results The level of plasma homocysteine of patients in stroke group was significantly higher than that of control group（P〈0.05）, and the level of plasma homocysteine of the LAA and PAO groups higher than other stroke group（P〈 0.05）, there were not significant diference between the other stroke group （P〈 0. 05）. Conclusion These findings showed plasma homoeysteine are risk predietors in ischemic cerebral stroke, and especially its involvement in the stroke of LAA,PAO. the level of plasma homocysteine have clinical significance for CISS criteria.