中文摘要：

以原子构成论为基石的近现代科学在描述简单机械物理系统以外的对象诸如量子现象、宇宙演化和复杂系统时遭遇到挑战。本文在分析这种危机实质的基础上提出以生成性本原来取代原子。针对这个主客体相融的、表达自由意志的开放实在，提出用更为广泛的广义信息概念取代力、物质和能量，从广义信息动力学角度建立起包容近现代科学的一个全新科学框架构想，以作为解释物理、化学、生物、生态、社会和经济等广泛领域中存在的大自然现象的指导思想，并最终实现跨学科的统一。

英文摘要：

Atomistic constructivism as foundation of modern sciences has been seriously challenged recently beyond simple mechanistic physical systems e.g. quantum phenomena, cosmic evolution and complex systems. By analyzing the disability of atomism, a generative origin instead of atom is proposed as building blocks for everything. Generalized information instead of force, matter and energy is suggested to describe the physical laws for the open reality with free will. Basing on the open reality with free will, a new generalized scientific paradigm with western modern sciences is then elaborated from dynamics of generalized information. This new paradigm proposed a complete and unified framework to deal with the interdisciplinary problems ran across wide field of physics, chemistry, biology, ecology, sociology and economy.