中文摘要：

探讨氧化应激DNA损伤水平在活动性Graves眼病（Graves’ophthalmopathy，G0）患者经糖皮质激素治疗后的变化情况。与对照组和Graves病（GD）组相比，GO组的血清8-羟基脱氧鸟嘌呤（8-hydroxy-deoxyguanosine，8-OHdG）显著增高（P〈0．05）；GO患者经糖皮质激素治疗后血清8-OHdG水平及临床疾病活动分数（clinicalactivityscoYe）较治疗前显著降低（P〈0．05）；治疗后的血清8-OHdG水平低于GD组（P〈0．05）。氧化应激参与GO的发病，GO患者的血清8-OHdG水平经糖皮质激素治疗后明显下降，可作为判断GO治疗效果的良好指标。

英文摘要：

The change in serum level of 8-hydroxy-deoxyguanosine （8-OHdG）, an oxidative stress biomarker, in patients with active Graves＇ ophthalmopathy （GO） during corticosteroid treatment was observed. The serum level of 8-OHdG was significantly increased in patients with active GO as compared with that of normal controls and patients with Graves＇ disease （P 〈 0.05 ）. After systemic corticosteroid treatment, patients with GO showed significantly lowered 8-OHdG level as compared with that before treatment and patients with Graves＇ disease. These changes in serum 8-OHdG level were accompanied by decreases in clinical activity score （P 〈 0. 05 ） during corticosteroid treatment. Oxidative stress may play a role in the pathogenesis of GO. Serum 8-OHdG level may be used as an objective and quantitative parameter in patients with GO during immunosuppressive treatment.