中文摘要：

目的：比较自行合成的3种可聚合季铵盐单体对口腔常见致病菌的抗菌活性及抗菌时效性。方法：采用液体稀释法比较季铵盐单体对4种口腔常见致病菌的抗菌活性,以抗菌性能最佳的单体进行杀菌动力学研究。结果：3种季铵盐单体对4种口腔致病菌均表现出一定的抗菌活性,其中DMAE-CB抗菌效果优于另外2种单体,该单体在浓度19.2μg/ml（4倍MBC值）时接触5min,99.889%的变形链球菌被杀灭;接触10min,即可杀灭所有细菌。结论：3种抗菌单体对口腔常见致病菌均具有不同程度的抗菌活性,DMAE-CB具有进一步应用于牙科抗菌修复材料的前景。

英文摘要：

Objective：To compare the antibacterial activities of three polymerizable quaternary ammonium salt monomers on oral pathogenic bacteria,furthermore to investigate the time-kill kinetics of the monomer to S.mutans.Methods：The antibacterial activities of the monomers were investigated by using the broth dilution test on oral pathogenic bacteria.The most effective monomer was further tested for time-kill kinetics.Results：The tested bacteria were all susceptible to the three monomers.DMAE-CB exhibited the lowest MICs ranging from 1.2 μg/ml to 4.8 μg/ml.Time-kill curve showed that DMAE-CB gave 99.44% killing rate at 19.2 μg/ml（4＊MBC） against S.mutans after 1 min and 100% killing rate within 10 min.Conclusion：Three quaternary ammonium salt monomers have different antibacterial activities on oral pathogenic bacteria.These data indicate that DMAE-CB may be a candidate antibacterial agent for oral infectious diseases.