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肝脏慢性病毒感染对结直肠癌肝转移发生及生存影响
  • ISSN号:1674-0785
  • 期刊名称:Chinese Journal of Clinicians(Electronic Edition)
  • 时间:2012
  • 页码:-
  • 分类:R735.35[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]中山大学附属第六医院结直肠肛门外科,广州510655, [2]中山大学附属第一医院胃肠胰外科
  • 相关基金:国家自然科学基金(81072046)
  • 相关项目:组织免疫微环境与结直肠肿瘤侵袭、转移的关系研究
中文摘要:

目的探讨肝脏慢性病毒感染对结直肠癌肝转移发生率影响,分析感染者和无感染者病倒总体生存情况。方法回顾性研究2868例结直肠病例,根据外周血检测结果分为感染组和无感染组,比较两组患者肝转移发生率,分析两组患者总体生存情况及比较两组肝转移患者生存时间。结果两组病例肝转移发生率比较差异有统计学意义(P〈0.05),5年总体生存率感染组优于无感染组,肝转移伴病毒感染组中位生存期26个月,无感染组20个月,两组比较差异有统计学意义(P〈0.001)。结论肝脏慢性病毒感染可降低结直肠癌肝转移发生率,有肝脏慢性病毒感染者病例总体预后优于无感染组,肝转移患者伴肝脏慢性病毒感染预后较好。

英文摘要:

Objective To investigate the effect of chronic hepatic virus infection on colorectal cancer liver metastases,and analysis the survival between infected group and non-infected group. Methods 2868 colorectal cancer patients were retrospectively analyzed. According to the peripheral blood test, patients were divided into infected group and non-infected group. The incidence of liver metastases and survival were compared, patients with liver metastases survival time were also compared. Results Significant differences were found between two groups (P 〈 0. 05 ), 5 years overall survival in infected group were better than control group. Colorectal cancer liver metastases with hepatic virus infection showed the median survival time 26 months, while the non-infected group 20 months. Conclusions Chronic hepatic virus infection decrease the risk of colorectal cancer liver metastases, also show the better oncology outcome for these patients. Colorectal cancer liver metastases with hepatic infection show better prognosis and longer survival time.

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期刊信息
  • 《中华临床医师杂志(电子版)》
  • 主管单位:
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京市西直门北大街32号B座606C室
  • 邮编:100082
  • 邮箱:lcdoctor@163.com
  • 电话:010-62219211
  • 国际标准刊号:ISSN:1674-0785
  • 国内统一刊号:ISSN:11-9147/R
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),波兰哥白尼索引
  • 被引量:30430