中文摘要：

目的研究1-溴丙烷对两种雄性大鼠的生殖毒性。方法将18只Fischer 344大鼠和18只Wistar大鼠分别随机分为两组，一组给予新鲜空气，一组给予1000ppm 1-溴阿烷，每天8h，连续暴露4周。在显微镜下对附睾的精子活动率和形态进行评价；睾丸等生殖器官进行了病理学评价。结果1-溴丙烷的暴露可引起大鼠的体重及生殖器官重量的下降；附睾的精子数减少、活动率下降、形态异常的精子增多；睾丸病理切片观察到曲精小管的精子释放延迟以及附睾的病理变化。结论1-溴丙烷暴露对两种雄性大鼠的生殖系统产生毒性影响，提示1-溴丙烷也可能对男性工人生殖系统产生不良影响．

英文摘要：

Objective To study the reproductive toxicity of 1-bromopropane to male rats by inhalation. Method Eighteen Fischer344 male rats and 18 Wistar male rats were randomly divided into 2 groups respectively, one subgroup of each group was exposed to fresh air and the other subgroup was exposed to 1 000 ppm of 1-bromopropane, 8h per day for 4 weeks. Then, the motility and form of＂ sperms in epididynfides, the weights and pathological changes of＂ testes, epididymides, seminal vesicles, and other parts of reproductive organs were all examined. Result At the end of the experiment, the body weights and the weights of reproductive organs in exposed rats were all reduced significantly, the amount and the motility of epididymal sperms were also decreased, while the cacospermia such as tailless sperms, immature head sperms increased. Additionally, retained, elongated spermatids near the 13asement membrane at the spermatogenesis cycle IX--XI were found. Conclusion The exposure to 1-bromopropane shows definite toxic effects on the reproductive system of＂ male rats, suggesting that this solvent may also have some adverse effects on reproductive system in male workers.