中文摘要：

早期生长反应基因1（Egr-1）启动子为Egr-1上游的顺式作用元件,其活性受电离辐射、自由基等诱导剂的调控.Egr-1与治疗基因结合（如肿瘤坏死因子α基因、自杀基因等）构成基因-放射治疗体系,利用辐射在肿瘤局部从时间、空间调控治疗基因的表达,使表达产物局限于肿瘤局部发挥肿瘤杀伤效应,并降低了不良反应.放射治疗与基因治疗的结合为肿瘤治疗提供了新方法.

英文摘要：

The promoter of early growth response gene-1 （Egr-1） is a cis-acting element of Egr-1, and its activity is regulated by inducers such as ionizing radiation, free radical. In designated gene-radiotherapy system, radiation combined with therapeutic gene （such as tumor necrosis factor-α gene, suicide gene） can spatially and temporally regulate therapeutic gene expression in the irradiated field, produced a marked effect,while little systemic toxicities were observed. The combination of radiotherapy and gene therapy is promising in tumor therapy.