中文摘要：

背景：对加压素的中等剂量低在败血或在心脏的外科以后在 cathecholamine 依赖的 vasodilatory 吃惊的治疗被使用了。我们在心脏的外科以后与 vasodilatory 吃惊在病人在 jejunal mucosal 灌注，胃动脉的 pCO ₂ 坡度和全球内脏的氧要求 / 供应关系上评估了加压素的效果。方法：八机械地通气了病人，依赖于新肾上素到因为 septic/post-cardiotomy vasodilatory 吃惊和多重机关失败，在心脏的外科以后维持吝啬的动脉的压力(地图)≥60 mmHg，被包括。加压素顺序为 30-min 时期在 1.2， 2.4 和 4.8 U/h 被灌输。新肾上素同时被减少在 75 mmHg 维持地图。以象胃动脉的 pCO ₂ 坡度(胃的 tonometry ) 和内脏的氧一样的加压素，全身的 hemodynamics 上的数据， jejunal mucosal 灌注， jejunal mucosal 分血器和红血房间速度(激光 Doppler flowmetry ) 的每注入率并且喂奶抽取(肝的静脉导管) 被获得。结果：心脏的索引，击体积索引和全身的氧交货减少了，全身的脉管的抵抗和全身的氧抽取显著地增加了，当心率或全球氧消费没随着增加加压素剂量变化时。Jejunal mucosal 灌注减少了， arterial-gastric-mucosal pCO ₂ 坡度增加了，当时内脏的氧或喂奶抽取或混合了静脉的肝的静脉的氧浸透坡度没被增加加压素的注入率影响。结论：注入对在有在心脏的外科以后的新肾上素依赖者 vasodilatory 吃惊的病人的加压素的中等剂量低导致肠、胃的 mucosal 血管缩小。

英文摘要：

AIM： To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy （^31p MRS） with the liver damage score （LDS） and pathologic changes in rabbits and to investigate the diagnostic value of ^31p MRS in acute hepatic radiation injury. METHODS： A total of 30 rabbits received different radiation doses （ranging 5-20 Gy） to establish acute hepatic injury models. Blood biochemical tests, ^31p MRS and pathological examinations were carried out 24 h after irradiation. The degree of injury was evaluated according to LD5 and pathology. Ten healthy rabbits served as controls. The MR examination was performed on a 1.5 T imager using a 1H/^31P surface coil by the 2D chemical shift imaging technique. The relative quantities of phosphomonoesters （PME）, phosphodiesters （PDE）, inorganic phosphate （Pi） and adenosine triphosphate （ATP） were measured. The data were statistically analyzed. RESULTS： （1） Relative quantification of phosphorus metabolites： （a） ATP： there were significant differences （P 〈 0.05） （LDS-groups：control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.55±0.24 vs 1.27±0.09 vs 0.98±0.18; pathological groups： control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.58±0.25 vs 1.32±0.07 vs 1.02±0.18） of ATP relative quantification among control group, mild injured group, moderate injured group, and severe injured group according to both LDS grading and pathological grading, respectively, and it decreased progressively with the increased degree of injury （r = -0.723, P = 0.000）. （b） PME and Pi; the relative quantification of PME and Pi decreased significantly in the severe injured group, and the difference between the control group and severe injured group was significant （P 〈 0.05） （PME： 1DS- control group vs LDS-severe group, 0.86±0.23 vs 0.58±0.22, P = 0.031; pathological control group vs pathological severe group, 0.86±0.23