中文摘要：

目的 对1株分离自疑似侵袭性肺曲霉病患者肺泡灌洗液的黄曲霉进行常用抗真菌药物敏感性的测定，判断其药物敏感性。方法 以形态学方法对该菌株进行菌种鉴定;然后按照美国临床和实验室标准研究所（CLSI）的丝状真菌抗真菌药物敏感性试验方案M38-A，测定常用抗真菌药物对该菌株的最低抑菌浓度、最低杀菌浓度;同时以E-test法测定该菌对两性霉素B和伊曲康唑的敏感性。结果 微量液基稀释法显示，两性霉素B或制霉菌素对该菌的MIC值均为4μg/ml，MFC值均为16μg/ml;伊曲康唑的MIC值为0.5μg/ml，MFC值为2μg/ml;特比萘芬的MIC为0.03μg/ml，MFC为0.03μg/ml。E-test法结果显示，该菌对伊曲康唑敏感，对两性霉素B耐药。结论 临床上可以分离到对多烯类抗真菌药物耐药的黄曲霉株，应该引起重视。

英文摘要：

Objective To assay the susceptibility of clinical Aspergillus flavus strain,which was isolated from hematological malignancy patient who had failed amphotericin B （AMB） therapy, to the common antifungal agents. Methods The minimal inhibitory concentration （MIC） of AMB, itraconazole （ITC）, terbinafine （TRB）, and nystatin （NYT） for the strain were assayed by using CLSI M38-A; the minimal fungicidal concentration （MFC） of these drugs for this strain were assayed in the same time. In addition, the susceptibility of this Aspergillus flavus strain to AMB and ITC were also assayed by E-test method. Results For this strain, the MICs of ITC, TRB, NYT, and AMB were 0. 5 g/ml,0. 03μg/ml,4μg/ml,and 4μg/ml, respectively;and the MFCs of these drugs for this strain were 2μg/ml,0. 03 μg/ml, 16μg/ml, and 16μg/ml, respectively. E-test result showed this strain was resistant to AMB but susceptible to ITC. Conclusion Aspergillusflavus strain, showing specific-resistance to polyene antifungal drugs, could be isolated from immuncompromised patient.