目的:探讨痤疮患者局部皮肤雄激素受体(AR)及性激素与中医相关证型的关系,从激素受体的角度揭示痤疮发生的机制。方法:选择70例典型面部痤疮患者作为观察对象,15例健康者作为对照组,采用皮肤雄激素受体、血清性激素、中医辨证为指标。结果:男、女性患者的睾酮(T)值均高于对照组(P〈0.01、P〈0.05);患病部位的局部AR阳性百分率显著高于非患病部位(P〈0.01),局部皮肤的AR与血清雄激素水平无相关性(P〉0.05);不同证型组AR阳性率以肾虚火旺型最高,但统计无显著差异(P〉0.05)。结论:痤疮发病不仅与血清T升高有关,同时与局部毛囊上皮细胞AR有关。T与AR是痤疮异证同病的物质基础。
Objective: To approach the relationship among skin androgen receptor(AR),sexual hormones and TCM syndromes in acne vulgaris,and to reveal the mechanism of acne vulgaris from the view point of hormone receptor.Methods: The indexes of AR,sexual hormones and differentiation of TCM syndrome were used in 70 patients with acne vulgaris,and 15 healthy persons as control group.Results:①Compared with control group,the testosterone in both male and female patients were higher than that in control group(P〈0.01,P〈0.05).②The positive rate of AR in Par aff skin was higher(P〈0.01)than that of unaffiliated part,but it was not co-related to blood serum androgen(P〉0.05).③The positive rate of AR in the group with flaming fire due to kidney deficiency syndrome was the highest,while it had no significant difference(P〉0.05).Conclusion: The mechanism of acne is not only related to the ascending of T,but also related to AR in follicular epithelial cells.The T and AR are the material basis of different syndrome with same disease in acne.