中文摘要：

分别使用带有巯基的化合物半胱胺（Cys）、胱胺（CYS）、巯基丁二酸（MSA）和巯基乙醇（ME）对金/二氧化硅纳米核壳粒子（GNs）进行表面化学修饰。利用动态光散射（DLS）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）和紫外-可见吸收光谱（UV-Vis）对修饰后的GNs进行表征。研究结果显示Cys和CYS修饰后GNs胶体溶液稳定性下降,核壳结构完整性破坏,从而导致其在近红外区最大吸收峰消失。而MSA和ME修饰的GNs胶体溶液稳定,金壳结构完整,光学性质稳定。这可能是由于Cys和CYS的胺基通过与金壳之间产生静电力作用和配位作用,破坏了GNs表面金壳。

英文摘要：

Gold nanoshells’ surface were modified by different functional small molecular containing mercapto group respectively, such as cysteamine （Cys）, cystamine （CYS）, mercaptosuccinic acid （MSA）, and mercaptoethanol （ME）. The investigations of dynamic light scatter （DLS）, transmission electron microscopy （TEM）, scanning electron microscopy （SEM） and UV-Vis spectra demonstrated that Cys and CYS with amine groups presented a significant devastation on the core/shell structure of gold nanoshells, which lead to the obvious aggregation and the disappearance of the NIR resonance of the nanoparticles. However, the surface-modification with MSA and ME had no obvious effect on the core/shell structure and the NIR response of the gold nanoshells. It is possibly due to the bonding of amine groups in Cys and CYS with the gold layers of the nanoshells by electrostatic and coordination interaction.