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中文摘要：
缺血再灌注损伤（ischemia-reperfusion injury, IRI）是治疗缺血性心、脑血管疾病亟待解决的关键问题。钙调控是目前IRI研究中的重要课题。本文就心血管IRI的钙信号调节,包括IRI与钙超载的关系以及IRI与钙敏感性的关系作一综述。其中重点阐述了IRI钙信号调节的关键环节,包括生物膜受损通透性增加使外Ca~（2＋）内流增加、Na~＋-Ca~（2＋）交换蛋白逆向转运增强使大量Ca~（2＋）摄入细胞、肌浆网Ca~（2＋）-ATP酶活性下降导致Ca~（2＋）摄取功能障碍、收缩调控蛋白Rho激酶活性增加等。对IRI钙信号调节的关键环节的研究可为临床心血管IRI的防治提供重要策略和潜在靶点。
英文摘要：
Ischemia-reperfusion injury（IRI） has been recognized as a serious problem for therapy of cardiovascular diseases.Calcium regulation appears to be an important issue in the study of IRI.This article reviews calcium regulation in myocardial and vascular IRI,including the calcium overload and calcium sensitivity in IRI.This review is focused on the key players in Ca2＋ handling in IRI,including membrane damage resulting in increase in Ca2＋ influx,reverse-mode of Na＋-Ca2＋ exchangers leading to increased Ca2＋ entry,the decreased activity of sarcoplasmic reticulum（SR） Ca2＋-ATPase causing SR Ca2＋ uptake dysfunction,and increased activity of Rho kinase.These key players in Ca2＋ homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.
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