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中国2型糖尿病患者中的安慰剂效应
  • ISSN号:1674-5809
  • 期刊名称:《中华糖尿病杂志》
  • 时间:0
  • 分类:R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]北京大学人民医院内分泌科,100044
  • 相关基金:国家自然科学基金(81000334)
中文摘要:

目的系统评价瑞格列奈在中国T2DM患者中与其他口服降糖药物相比的相对疗效及安全性。方法在数据库中进行文献检索并设定人选研究标准,对入选研究进行荟萃分析。结果纳入96项研究。在降低HbA1c方面,瑞格列奈优于安慰剂及磺脲类药物(SUs),与α-葡萄糖苷酶抑制剂(AGIs)、那格列奈、二甲双胍、噻唑烷二酮(TZDs)相当;在降低FPG方面,瑞格列奈优于安慰剂、SUs及那格列奈,与AGIs、二甲双胍、TZDs相当;在降低餐后血糖方面,瑞格列奈与那格列奈和TZDs相当,优于安慰剂、AGIs、二甲双胍及SUs。结论本研究更全面地提供了瑞格列奈相对于其他口服降糖药物在中国T2DM患者中与疗效及安全性相关的临床证据。

英文摘要:

Objective To evaluate the comparative efficacy and safety of repaglinide against other hypoglycemic agents in Chinese T2DM patients. Methods The MEDLINE, EMBASI and CENTRAL were searched and qualified studies were included. Results Totally 96 qualified studies were included. In terms of HbA1c decline, repaglinide treatment was superior to placebo (WMD: -0. 87%, 95%CI: - 1. 21%- 0. 53) or sulfonylureas (SUs) (WMD : - 0. 23%, 95% CI: -0. 41 - 0. 06), and was comparable with nateglinide, metformin, α-glucosidase inhibitors (AGIs) or TZDs. In terms of fasting glucose lowering, repaglinide treatment was superior to placebo (WMD: -1.50 mmol/L, 95%CI: -1. 95%-1.05), nateglinide (WMD: -0. 17 mmol/L, 95%CI: -0. 30%--0. 05) or SUs (WMD:-0.24 mmol/L, 95%CI: -0. 46%--0. 01), and was comparable with metformin, AGIs or TZDs. In terms of postprandial glucose lowering, repaglinide treatment was superior to placebo, AGIs, metformin or SUs, and was comparable with nateglinide or TZDs. In terms of BMI, repaglinide treatment was superior to SUs. In terms of hypoglycemic rate, repaglinide treatment was superior to SUs, and was comparable with nateglinide. Conclusion This Meta-analysis provides more comprehensive clinical evidence on the comparative efficacy and safety of repaglinide in treating Chinese T2DM patients.

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期刊信息
  • 《中华糖尿病杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京市东四西大街42号
  • 邮编:100710
  • 邮箱:office@cma.org.cn
  • 电话:010-85158180
  • 国际标准刊号:ISSN:1674-5809
  • 国内统一刊号:ISSN:11-5791/R
  • 邮发代号:80-994
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:4248