中文摘要：

目的评价敏感编码螺旋（Sense-Spiral）成像技术在静息态fMRI中的图像质量及其应用。方法分别采用EPI和Sense-Spiral序列采集50名健康青年志愿者的静息状态fMRI数据,比较所得数据的相对信号强度和伪影严重程度,及对默认模式网络（DMN）和其功能连接的显示能力。结果与EPI序列相比,Sense-Spiral序列具有更高的灰白质对比度,显著改善了内侧眶额皮层、腹侧基底核区、颞极、颞下回前部和小脑半球的信号丢失和图像变形。Sense-Spiral序列可准确构建DMN,其内后扣带皮层与内侧眶额皮层、中扣带回/楔前叶前部的功能连接强度高于EPI序列,与内侧枕叶、楔前叶后下部、双侧角回及颞中回后部的功能连接强度低于EPI序列（P〈0.05,FWE校正）。结论 Sense-Spiral序列可明显改善静息态fMRI的图像质量,尤其适用于EPI图像伪影严重脑区的功能连接分析。

英文摘要：

Objective To assess the image quality of Sense-Spiral sequence in resting-state fMRI and its preliminary application.Methods Resting-state fMRI data were collected in 50 healthy young volunteers by Sense-Spiral and EPI,respectively.Relative signal intensity,artifact and its functional connectivity in default mode network（DMN）were compared between the two acquisition methods.Results Compared with the EPI,the Sense-Spiral sequence had a better contrast between gray and white matter and substantially reduced signal loss and image distortion in the medial orbitofrontal cortex,ventral basal ganglia,temporal pole,anterior and inferior temporal gyrus and cerebellar hemispheres.Sense-Spiral could accurately reconstruct the DMN and the posterior cingulate cortex showed significant higher functional connectivity strengths with the orbitofrontal cortex,middle cingulate gyrus and anterior precuneus,but lower functional connectivity strengths with the bilateral angular gyrus,middle temporal gyrus,posterior cingulate cortex,and medial occipital cortex in the Sense-Spiral sequence compared to those in the EPI sequence（P〈0.05,FWE corrected）.Conclusion Sense-Spiral sequence can significantly improve image quality of resting-state fMRI,whith is especially suitable for analyzing functional connectivity in brain regions with obvious artifacts in EPI images.