中文摘要：

全世界范围内灾难性事件的频发使得创伤后应激障碍（PTSD）已经成为一个重要的公共卫生问题。作为一种与应激有关的精神性疾病,PTSD是基因和环境（尤其是早期负性经历）共同作用的结果,表观遗传修饰发挥着重要作用。基于下丘脑-垂体-肾上腺（HPA）轴在PTSD发病中的核心作用,该文对国内外近年来有关HPA轴相关基因表观遗传学与PTSD发病之间关系的研究进行综述,以期为今后PTSD的防治提供思路和理论参考。

英文摘要：

Currently,the worldwide frequency of catastrophic events has made post-traumatic stress disorder（ PTSD） a major public health problem. As a stress-related psychiatric disorder,PTSD is considered as the result of interaction between gene and environments（ especially early life adversity）. The epigenetics plays an important role in PTSD pathogenesis. Due to the core role of hypothalamic-pituitary-adrenal（ HPA） axis,the research on the relationship between HPA axis epigenetics and PTSD pathogenesis in recent years was reviewed in the paper so as to provide references and thinking of the prevention and therapy for PTSD in the future.