中文摘要：

磷脂酰肌醇3-激酶（PI3Ks）作为酪氨酸激酶和G蛋白偶联受体的主要下游分子,通过催化产生第二信使3,4,5-三磷酸磷脂酰肌醇（PIP3）并激活Akt、糖原合酶激酶-3（GSK-3）、Forkhead转录因子FoxO1、mTOR（mammalian target of rapamycin）等下游分子,将多种生长因子及细胞因子的信号传递到细胞内,从而对细胞增殖、分化、凋亡和葡萄糖转运等多种生物过程起重要的调节作用.PTEN（phosphatase and tensin homologue）是PI3K信号通路的重要负调节因子.本文将对PI3K-Akt信号通路在糖代谢中的作用予以简要综述.

英文摘要：

Phosphoinositide 3-kinases （PI3Ks） is one of the main downstream molecules of receptor tyrosine kinases and G protein-coupled receptors.Activated PI3Ks catalyzes the production of second messenger phosphatidylinositol-3,4,5-trisphosphate （PIP3）,which phosphorylates Akt.Activation of Akt plays vital roles in regulation of cell proliferation,differentiation,apoptosis,glucose transportation and metabolism via its downstream enzymes or transcriptors such as glycogen synthase kinase-3,FoxO1,and mammalian target of rapamycin （mTOR）.The current review aims to briefly summarize and discuss the recent findings regarding the roles of PI3K-Akt signaling axis in regulation of glucose homeostasis.