中文摘要：

目的：采用Alamar blue法及MTT法观察波罗蜜属药用植物单体化合物（ACR-2、ACR-3）对人肝癌细胞（SMMC-7721）和胃腺癌细胞（SGC-7901）增殖的影响。方法：用Alamar blue法和传统MTT法检测ACR-2、ACR-3对细胞SMMC-7721、SGC-7901的增殖抑制作用。结果：ACR-2作用于细胞SMMC-7721和细胞SGC-7901的IC50（mmol／L）分别为0．013和0．059；ACR-3作用于细胞SMMC-7721和细胞SGC-7901的IC50（mmol／L）分别为0．029和0．169。其中ACR-2、ACR-3对细胞SMMC-7721的增殖抑制作用最强，对细胞SGC-7901也表现出较强的增殖抑制作用。时量曲线检测结果显示：ACR-2、ACR-3对细胞SMMC-7721、SGC-7901的增殖抑制作用具有时间和剂量依赖性，其增殖抑制作用以48h时最强。结论：波罗蜜属药用植物单体化合物ACR-2、ACR-3对人肝癌细胞SMMC-7721、胃腺癌细胞SGC-7901有明显的增殖抑制作用，且有时间和剂量依赖性。

英文摘要：

Objective：To investigate the inhibitory effects of ACR -2 and ACR- 3,monomefic compounds which were isolated from the medical plant jaekfruit, on SMMC - 7721 and SGC - 7901 cell lines. Methods ： SMMC - 7721 and SGC - 7901 cells were treated with ACR-2 and ACR-3 ,the anti -proliferative effect was measured by using the micro culture Alamar blue and MTT assays. Results：ACR- 2 and ACR- 3 can inhibit the cell proliferation of SMMC -7721 and SGC- 7901 cells ,in a time- and dose - dependent manner; IC50 （mmol/L） of ACR - 2 and ACR - 3 on SMMC - 7721 cell line were 0. 013 and 0. 029; IC50 （mmol/L） of ACR - 2 and ACR - 3 on SGC - 7901 cell line were 0.095 and 0. 169. Conclusion ： ACR - 2 and ACR - 3 hold very significant inhibitory effects on the SMMC -7721 and SGC -7901 cell lines with a time- and dose-dependent manner.