目的采用与介孔材料复合的方式提高难溶性药物水飞蓟宾的溶出速率。方法通过X射线衍射、氮气吸附-脱附曲线、差示扫描量热分析及透射电镜观察水飞蓟宾负载到SBA-15的表面情况。气相色谱法检测水飞蓟宾负载后的丙酮残留情况。溶出速率实验研究水飞蓟宾负载到SBA-15的表面效果。结果 X射线衍射、氮气吸附-脱附曲线与差示扫描量热分析表明水飞蓟宾以非晶的形式负载在SBA-15的孔道内表面,负载前后的透射电镜图片显示无显著差异。气相色谱检测法表明丙酮残留符合要求。溶出速率实验表明负载后水飞蓟宾的溶出速率显著提高。结论本实验为提高难溶性药物的溶出速率提供了一条新途径。
OBJECTIVE To improve the dissolution rate of silybin by loading it into SBA-15 mesoporous silica.METHODS The adsorption of silybin on the surface of SBA-15 was observed by X-ray diffraction,N2 adsorption-desorption isotherms,differential scanning calorimeter experiments and TEM.A GC method was established for the determination of residual acetone in SBA-15/SB.The effect of silybin attachment on the surface of SBA-15 was investigated in dissolution experiment.RESULTS X-ray diffraction,N2 adsorption-desorption isotherms and differential scanning calorimeter experiments showed that amorphous silybin was densely and uniformly loaded on the surface of the pore in SBA-15.There was no difference between SC and SBA-15/SB in the image of TEM.The quantity of residual acetone in SBA-15/SB met the requirement as showen by GC.The dissolution experiment indicated that the dissolution rate of composite was increased significantly compared to crystalline silybin.CONCLUSION This study provides a new way to improve the dissolution rate of poor water soluble drugs.