中文摘要：

恩诺沙星是一种抗菌药物,广泛应用于畜禽养殖业和水产养殖业。随着恩诺沙星使用量的不断增加,在其对细胞色素P450酶系的影响方面已有广泛的研究。介绍了细胞色素P450酶的基本特征,综述了恩诺沙星对细胞色素P450酶系影响的研究进展,以期为进一步阐明恩诺沙星与细胞色素P450酶系的相互作用机制及恩诺沙星在畜禽体内的药理学与毒理学特征提供理论依据。

英文摘要：

Enrofloxacin, belonging to the third generation of fluoroquinolone, is a kind of antibiotic with broad antibacterial spectrum and is widely applied in livestock and poultry breeding and aquaculture. With the increasing amount of enrofloxacin used in agriculture production, its effect on cytochrome P450 enzyme system is also widely investigated. Here we introduced the basic characteristics of cytochrome P450 enzyme and reviewed the research progress on effect of enrofloxacin on cytochrome P450 enzyme system, so as to provide reference for further understanding of interaction mechanism between enrofloxacin and cytochrome P450 enzyme system as well as pharmacologic and toxicologic features of enrofloxacin in livestock and poultry.