中文摘要：

合胞素-1（syncytin-1）是人类生殖系统普遍存在的一种包膜蛋白,孕早期定位于绒毛膜滋养层,在胎儿发育过程中起重要作用,其异常表达可导致宫内发育迟缓、病理性胚胎、肿瘤和多发性硬化症等。本文将对syncytin-1的形成、功能与肿瘤相关的激活调控途径等进行综述。

英文摘要：

Syncytin-1 is a common protein in human reproductive system envelope, which is located in the first trimester trophoblast and plays an important role in the fetus development. The abnormal expression may lead to intrauterine growth retardation, pathological embryonic, tumor and multiple sclerosis. This paper will give an overview of syncytin-1 on synthesis, function, association with cancer and relationship with regulatory pathway on tumor activation.