中文摘要：

以1，3-环己二酮和香叶醇为起始原料，通过12步反应，合成了具有3／6／5三环骨架的关键中间体4．其中关键反应有：[3，3]重排反应一步构筑两个相邻的全碳季碳中心；Grubbs一2nd催化剂催化的关环复分解反应构筑5元环；Simmons—Smith环丙烷化反应构筑3元环．

英文摘要：

A key intermediate 4 with 3/6/5 tricyclic core was synthesized in 12 steps from 1, 3-cyclohexanedione and geraniol, paving the way for the total synthesis of Tenuipesine A. The developed synthetic strategy featured a [3, 3] rearrangment reaction to introduce two contiguous all-carbon quaternary centers; a ring closing metathesis reaction was catalyzed by Grubbs-2nd catalyst to form a five-membered ring; and a Simmons-Smith reaction was utilized to construct a cyclopropane moiety.