中文摘要：

2型糖尿病（type2diabetes mellitus,T2DM）与阿尔茨海默病（Alzheimer’s disease,AD）的病理生理过程具有密切的相关性。人们正在逐步深入研究治疗T2DM的最新药物——胰高血糖素样肽1（glucagon-likepe ptide1,GLP-1）的神经保护作用,并大胆地提出了利用GLP-1治疗AD的设想。本文对T2DM与AD的发病相关性、GLP-1的合成与分泌、GLP-1受体的中枢分布及其生理效应,特别是GLP-1与AD治疗策略相关的研究进展作一综述。

英文摘要：

There is a close correlation between type 2 diabetes mellitus（T2DM） and Alzheimer＇s disease（AD） in the course of pathophysiological processes.The neuroprotective action of glucagon-like peptide 1（GLP-1）,a latest drug for clinical treatment of T2DM,is being more deeply investigated at present,and a novel therapeutic strategy for AD with GLP-1 has been proposed boldly.This review mainly discussed the correlation of pathogenesis between T2DM and AD,the synthesis and secretion of GLP-1,the distribution and physiological effects of GLP-1 receptor in the brain,and the progresses on the study of GLP-1 in the treatment of AD.