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不同重建阈值构建宫颈癌动脉血管网数字化三维模型对癌灶血供分析的影响

ISSN号：1008-7427
期刊名称：《湖北广播电视大学学报》
时间：0
分类：TP3[自动化与计算机技术—计算机科学与技术] F71[经济管理—产业经济]
作者机构：[1]南方医科大学南方医院妇产科, 广州,510515, [2]南方医科大学南方医院南方医科大学数学人研究所, 广州,510515, [3]南方医科大学南方医院影像中心, 广州,510515
相关基金：国家自然科学基金(81272585，30970762，61190120)；广东省自然科学基金(2011010003830，10151051501000102)；南方医院高层次匹配课题(2010023)；南方医院2012年院长基金

作者：陆琳[1], 段慧[1], 陈春林[1], 刘萍[1], 王黎[1], 陈兰[2], 王俊[1], 李维丽[1], 陈瑞莹[3], 王建平[3], 唐雷[2], 钟世镇[2]

中文摘要：

目的：拟比较不同重建阈值的在体宫颈癌动脉血管网数字化三维模型的血供比例，评估模型的应用价值。方法通过采集2010年4月至2012年12月于南方医科大学南方医院妇科住院的36例宫颈癌患者的CTA数据集，导入三维重建软件后分别设定重建阈值为80 HU、100 HU和120 HU后利用Mimics软件构建在体宫颈癌动脉血管网数字化三维模型；利用线切割及面切割工具对三维模型进行立体切割，并计算子宫及子宫各部分的血管容积及血供比例，比较三种不同重建阈值所构建的在体宫颈癌动脉血管网数字化三维模型的血供特点。结果（1）通过Mimics软件计算得出，子宫总体血管容积、宫体血管容积、宫颈血管容积，宫体左/右侧部血管容积、宫颈左/右侧部血管容积随重建阈值降低而增加，差异具有统计学意义（P<0.05），子宫各部位血管容积与不同重建阈值之间呈负相关（P<0.01）；（2）宫体、宫颈占总体血供比例，宫体左/右侧部占宫体血供比例以及宫颈左/右侧部占宫颈血供比例不随重建阈值的变化而变化，差异无统计学意义（P>0.05）。结论宫颈癌动脉血管网数字化三维模型中子宫各部分血供比例不受重建阈值的变化而变化，能更客观准确的反映宫颈癌的动脉血供特点，为后续临床应用提供了稳定的模型基础。

英文摘要：

Objective Intends to compare the proportion of the blood supply of uterine arteries digital three-dimensional model of cervical cancer reconstructed by different threshold, and assess the applicative value of the models. Method The 36 CTA datasets of patients with cervical cancer were obtained from April 2010 to December 2012. All the patients were from the department of Obstetrics and Gynecology in Nanfang Hospital of Southern medical university. The uterine arteries digital three-dimensional models of cervical cancer were built on different reconstructive threshold such as 80 Hu, 100 Hu and 120 HU by Mimics software. Then the models were cut into different parts of uterus by using the line cutting and surface cutting tools, and the vascular volume and the proportion of blood supply were calculated to compare the characteristic of blood supply in three dimensional models reconstructed by different threshold. Results The vascular volume of overall uterus, corpus, cervix, left and right parts of corpus and cervix calculated by Mimics software decreased with the reconstructive threshold significantly (P<0.05). There was negative correlation between the vascular volume of each parts of the uterine and different reconstructive threshold. However, the proportion of the vascular volume of left and right parts of corpus and cervix accounted in overall uterus, corpus, cervix were not change due to the different reconstructive threshold (P>0.05). Conclusions The proportion of vascular volume in each parts of the uterine arteries digital three-dimensional model of cervical cancer were unaffected by the change of the reconstructive threshold. It could reveal the characteristics of blood supply in cervical cancer more objective and accurate, and provide a stable model foundation for subsequent clinical applications.

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