中文摘要：

目的：探讨中药康复新液经灌肠给药对2，4-二硝基氯苯联合醋酸诱导大鼠结肠炎的治疗作用。方法：采用灌肠给药方式对溃疡性结肠炎（UC）模型大鼠进行治疗，通过测定大鼠DAI指数、脏器指数，检测血清IL-4、IL-10的表达水平，观察结肠黏膜损伤程度及病理改变来评价康复新液对大鼠UC的影响。结果：阳性药美沙拉嗪及治疗药物康复新液均能改善UC大鼠结肠组织的病变程度，修复肠道受损黏膜，病理组织学评分明显下降并具有统计学意义（P〈0.01或P〈0.05），提示灌肠有明显的治疗效果；康复新液高、中、低剂量组均能不同程度的降低DAI评分、结肠指数，缓解黏膜水肿，提高IL-4（P〈0.01）、IL-10（P〈0.01）的表达水平。从黏膜损伤及病理组织学评分可见康复新液组促进溃疡面愈合的效果更优。结论：康复新液对DNCB联合醋酸诱导的UC大鼠有治疗作用，可有效促进UC大鼠结肠溃疡的愈合，能有效的减轻UC大鼠的腹泻症状（DAI评分降低）。

英文摘要：

Objective：To explore the effect of Kangfuxin solution through enema adimistration to ulcerative colitis rat model, which was made by the treatment of 2, 4-dinitrochlorobenzene combined with acetic acid. Methods：Ulcerative colitis rats were treated by enema adimistration. For evaluating the effect of Kangfuxin solution on ulcerative colitis rats, the damaged intestinal mucosa and pathological changes were observed through the determination of DAI, viscera index of rats, the expression level of serum IL-4 and IL-10. Results： It was showed that positive medicine mesalazine and Kangfuxin solution both can improve the UC rats colon tissue lesions, repair the damaged intestinal mucosa, decrease histologic grade markedly（P〈0.01 or P〈0.05）and the effect of enema is obvious. The different doses of Kangfuxin solution can reduce DAI score, colon index and inflammation, alleviate mucosal edema and enhance IL-4（P〈0.01）and IL-10（P〈0.01）expression level. The effect of alleviating mucosal edema and promoting healing of ulcer surface of Kangfuxin group was improved. Conclusion：Kangfuxin solution plays an active role in treating the inflammation of UC rats which is induced by 2,4-dinitrochlorobenzene and acetic acid, promoting the healing of UC rats colon ulcer and reducing the diarrhea of UC rats（DAI score lower）.