中文摘要：

肿瘤的发生发展与抑癌基因的失活和原癌基因的激活密切相关。对抑癌基因失活机制的深入研究，不但可揭示肿瘤发生发展的机制，同时也有助于肿瘤的诊断及基因治疗。

英文摘要：

Inactivation of tumor suppressor gene （TSG） and activation of oncogenes play important roles in development and progression of tumors. Further research on TSG can not only reveal the development and progression of tumors,but also help the diagnosis and gene therapy of tumors. This review will address the research advances of TSG inactivation mechanism.