中文摘要：

NEDD8 （neural precursor cell-expressed developmentally downregulated 8）分子是一类结构上与泛素相似的分子，参与蛋白质翻译后修饰，这一过程被称为Neddylation．Neddylation的发生机制与泛素化相似，需要E1、E2、E3介导的一系列酶促反应．Neddylation修饰在Cullin—Roc类泛素连接酶的活性调控中具有至关重要的作用，与泛素化研究相比，在真核细胞内仅发现了很少的能被Neddylation修饰的底物，Neddylation的生理功能也有待深入研究．

英文摘要：

NEDD8 is a member of the ubiquitin-like proteins. The overall structure of NEDD8 is quite similar to ubiquitin. Covalent conjugation of NEDD8 to proteins at the post-translational level is called Neddylation. Neddylation occurs similarly to ubiquitination and need enzyme cascades involving El, E2 and E3. Neddylation has been demonstrated to be essential to maintain the ubiquitin ligase activity of Cullin-Roc based E3 ligases. Compared with the ubiquitination which was widely studied in the past two decades, few substrates were identified for Neddylation and the physiological functions of Neddylation need further investigations. The current progress of function and regulation of protein Neddylation will be reviewed.