中文摘要：

类风湿性关节炎是一种慢性炎症性系统性的自身免疫性疾病,发病可累及多关节以及全身多个系统。其发病机制与多种细胞因子有着密切的关系。Th17细胞是T细胞新发现的亚群,经研究证实其分泌的IL-17等多种细胞因子能诱导严重的自身免疫性反应。JAK/STAT信号通路,尤其是STAT3信号通路对类风湿慢性炎症有着重要的正反馈促进作用。Th17细胞的分化与调节机制和STAT3信号通路正反馈调节作用的进一步研究可以为探索类风湿性关节炎的治疗方法提供新的思路。

英文摘要：

Rheumatoid arthritis is a chronic inflammatory autoimmune disease which can attack multi-joint and may affect multi-system.The participation of a variety of cytokines plays extremely vital role in the pathogenesis of RA.Th17 cell,as the latest discovered T cell subset,can secrete many cytokines like IL-17 which have been verified possessing the ability to induce serious autoimmune disease.The deficiency of Th17 cell can effectively alleviate or even treate autoimmune diseases.JAK / STAT signaling pathway,especially the STAT3 signaling pathway,is the significant positive feedback for the differentiation of Th17 cell.Consequently,to figure out the cellular differentiation and regulatory mechanism of Th17 cell and the positive feedback of STAT3 signaling pathway can point a span-new breakthrough direction to treat RA.