中文摘要：

特应性皮炎（atopic dermatitis，AD）是一种常见的慢性复发性炎性皮肤病，遗传与环境交互作用在其发病中起重要作用。研究发现FLG基因与金黄色葡萄球菌、花生过敏原、家庭养猫、多同胞数，神经肽S受体1基因与益生菌，谷胱甘肽硫转移酶基因与健康饮食、香烟烟雾暴露之间存在相互作用。深入挖掘遗传与环境因素的相关性，将为揭示AD发病机制提供新的契机。

英文摘要：

Atopic dermatitis （AD） is a common, chronic, recurrent and inflammatory skin disease. The interactions between genes and environment are critical in the development of AD. Studies have shown significant interactions between FLG gene and Staphylococcus aureus, peanut allergen, eat exposure, siblings;NPSR1 gene and probiotics; GSTs gene and traditional healthy diets, smoke exposure. Therefore, investigating the association between genes and environment provides a new avenue to further reveal the pathogenesis of AD.