thermophiles 的病毒由于他们在基因转移,全球 geochemical 周期和在地球上的生活的进化的角色兴趣大。然而, thermophilic 抗菌素没广泛地被学习。在这调查,典型抗菌素 BV1 从 thermophilic 细菌 Geobacillus sp 被获得。6k512,它在中国的厦门从一个沿海的温泉被孤立。包含的 BV1 35 055 bp 的线性 DNA,它编码 54 开的读物装裱的双 stranded (ORF ) 。有趣地, ORF 分享了的 54 BV1 中的八个从人的疾病相关的细菌定序类似到基因。净化的 BV1 virions 的七蛋白质被 proteomic 分析识别。BV1 功能的 genomics 的决心将为 virus-thermophile 相互作用便于机制的更好的理解。
Viruses of thermophiles are of great interest due to their roles in gene transfer, global geochemical cycle and evolution of life on earth. However, the thermophilic bacteriophages have not been studied extensively. In this investigation, a typical bacteriophage BV1 was obtained from a thermophilic bacterium Geobacillus sp. 6k512, which was isolated from an inshore hot spring in Xiamen of China. The BV1 contained a double-stranded linear DNA of 35 055 bp, which encodes 54 open reading frames (ORFs). Interestingly, eight of the 54 BV1 ORFs shared sequence similarities to genes from human disease-relevant bacteria. Seven proteins of the purified BV1 virions were identified by proteomic analysis. Determination of BV1 functional genomics would facilitate the better understanding of the mechanism for virus-thermophile interaction.