目的:研究乳腺疾病术后疗效与中医证型之间的相关性。方法:选取手术治疗的乳腺增生症患者60例和乳腺癌患者40例作为研究对象,观察手术治疗后中医不同证型的乳腺增生症和乳腺癌患者的临床疗效,判断预后情况。结果:术后乳腺增生症肝郁气滞证治愈率最高、气滞血瘀证治愈率最低。乳腺癌预后因子表达中,常见证型的病理分级及肿瘤组织的 ER、PR、p53表达无显著性差异(P >0.05)。肝郁脾虚证患者肿瘤组织的 Her-2/neu 阳性率及 VEGF 阳性率最低,痰瘀毒热证患者肿瘤组织的 Her-2/neu 阳性率及 VEGF 阳性率最高。乳腺癌肝郁脾虚证患者术后无病生存率最高,痰瘀毒热证患者总生存率最低。结论:手术对肝郁气滞型乳腺增生症和肝郁脾虚型乳腺癌治疗效果较好。
Objective:Study of the correlation of postoperative effect of breast disease and TCMsyndromes.Methods:Choose patients with breast hyperplasia in 60 cases and breast cancer patients in 40 cases as the object and observe clinical effect of different TCM Syn-dromes of breast hyperplasia and breast cancer patients after surgical treatment and prognosis judgment.Results:The postoperative breasthyperplasia liver qi stagnation syndrome had higher cure rate and qi stagnation and blood stasis had low cure rate.Expressions in breast cancer prognosis factor,the common syndromes of pathological grading and tumor tissue of Er,PR,p53 expression had no signifi-cant difference(P 〉0.05).The HER-2 /neu positive rate and the positive rate of VEGF of stagnation of liver-QI with deficiency of the spleen patients were lowest.Phlegm and blood stasis in the tumor tissue of patients had highest HER-2 /neu positive rate and VEGF pos-itive rate.Breast cancer of liver stagnation and spleen deficiency syndrome patients had highest survival rate and phlegm and blood sta-sis poison heat patients had lowes survival rate.Conclusion:Operation has better therapeutic effect on hyperplasia of mammary gland disease and liver Qi stagnation of liver stagnation and spleen deficiency syndrome type of breast cancer.