中文摘要：

目的对连接叶酸主动靶向头的水飞蓟宾固体脂质纳米粒（FA-SIL-SLN）进行大鼠体内药动学和小鼠体内靶向性研究。方法大鼠或小鼠尾iv给予水飞蓟宾（silybin,SIL）水溶液、水飞蓟宾固体脂质纳米粒（SIL-SLN）溶液和FA-SIL-SLN溶液,HPLC法检测不同时间血浆和各组织中SIL浓度,利用3P97软件统计学方法分析SIL在大鼠体内的药动学特征及小鼠体内靶向性。结果 FA-SIL-SLN与SIL水溶液组和SIL-SLN组相比具有良好的缓释能力和长循环特性,肺部相对摄取率（re）为SIL水溶液的3.98倍;相对靶向系数（te）为SIL水溶液的2.85倍,同时,能减少药物在心脏和肾脏中的分布。结论 SIL-SLN、FA-SIL-SLN具有明显的缓释作用及肺部靶向性,可降低药物对心脏、肾脏的毒副作用。

英文摘要：

Objective The silybin solid lipid nanoparticles （SIL-SLN）, which is connected folic acid （FA） active targeting head, were studied on the in vivo pharmacokinetics of rats and in vivo targeting of mice. Methods SIL solution, SIL-SLN, and FA-SIL-SLN were iv injected by tail of rats or mice, respectively. The SIL concentration in the plasma and tissues was detected by HPLC method at different time points. The in vivo pharmacokinetic characteristics in rats and in vivo targeting data in mice were analyzed by statistical methods with 3P97 software. Results Compared with solution group and SIL-SLN group, FA-SIL-SLN has good sustained-release ability and long-cycle characteristics, re value of the lung in FA-SIL-SLN is 3.98 times higher than that in the control group, and t_e value is 2.85 times higher than that in the SIL solution group; Meanwhile, it can reduce the drug distribution in heart and kidney. Conclusion The in vivo tests show that SIL-SLN and FA-SIL-SLN have the obvious sustanined-release effect and lung targeting, and also can reduce the toxicity of drugs in heart and kidney.