中文摘要：

目的：优选浙贝母中总生物碱的超声波提取工艺。方法：选取提取时间、超声波功率和液料比为随机因子。在单因素试验的基础上，进行3因素3水平的Box-Behnken试验设计，以总生物碱得率为响应值进行分析。结果：最佳提取条件为提取时间48min、超声波功率420W、液料比6．6（mL：g）。在此条件下，总生物碱得率验证值为0．1685％。结论：响应面法优选浙贝母中总生物碱的超声波提取工艺简便、易行。

英文摘要：

OBJECTIVE： To optimize the ultrasonic extraction technology of total alkaloid from Fritillaria thunbergii. METHODS： Extracting time, ultrasonic power and liquid-solid ratio were selected as casual factors, based on single-factor experiments, three-factor-three-level Box-Behnken experiment design method was applied, and the extraction rates of total alkaloid were used as response values for response surface methodology （RSM） analysis. RESULTS： The optimum conditions of ultrasonic extraction were as follows： extraction time of 48 min, ultrasonic power of 420 W, and liquid-solid ratio of 6.6 （mL：g）. Under these conditions, the extraction rate of total alkaloid was 0.168 5%. CONCLUSION： The extraction process optimized by RSM analysis is simple and more convenient for extracting total alkaloid from E thunbergii.