欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
趋化因子受体5（CCR5）是HIV-1侵入宿主细胞的主要辅助受体之一。目前已发现许多小分子CCR5拮抗剂，其中一些化合物已进入临床研究和应用。本文介绍了小分子CCR5拮抗剂的作用机制，综述了近几年来各种不同结构类型的小分子CCR5拮抗剂的研究进展。
英文摘要：
C-C chemokine receptor type 5 （CCR5） has been recognized as a major co-receptor in the HIV-1 entry process. Currently, many kinds of novel small molecule CCR5 antagonists for the treatment of AIDS have been identified and progressed into clinical trials. In this article, after brief introduction of the mechanism of action, current progress in drug research for various small molecule CCR5 antagonists is reviewed.
同期刊论文项目
同项目期刊论文
Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: synthesis and preliminary
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5- ylthio)-N-a
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonyl methylthio)-6-(2,6-d
1,2,3-thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcrip
Synthesis and Anti-HIV Activity Evaluation of Novel 2,4-Disubstituted 7-Methyl-1,1,3-trioxo-2H,4H-Py
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-on
Synthesis and anti-HIV activity evaluation of novel N ';-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazo
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reve
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-di
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-ac
Arylazolylthioacetanilide. Part 11: Design, synthesis and biological evaluation of 1,2,4-triazole th
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucl
Discovery of Novel 2-(3-(2-Chlorophenyl) pyrazin-2-ylthio)-N-arylacetamides As Potent HIV-1 Inhibito
Benzimidazole (Benzimidazolone) Heterocycle as A Privileged Scaffold in Antiviral Agents. Mini-Revie
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)met
Facile Synthesis of Derivatives of 1,1,3-Trioxo-2H,4H-pyrrolo[1,2-b] [1,2,4,6]thiatriazine: A New He
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of Novel 2-(2-(2,4-Di
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine de
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioac
Xiao Li, Peng Zhan*, Hong Liu, Dongyue Li, Liu Wang , Xuwang Chen, Huiqing Liu, Christophe Pannecouq
The HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors (Part V): Capravirine and Its Analogues. C
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-y
Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisost
Design, synthesis and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione d
Design, synthesis and biological evaluation of N2, N4-disubstituted- 1,1,3-trioxo-2H,4H-pyrrolo[1,2-
Diwakar Rai,Wenmin Chena, Ye Tian, Xuwang Chen,Peng Zhan, Erik De Clercq, Christophe Pannecouque, Ja
Synthesis and anti-HIV activity evaluation of novel N1-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-
Synthesis and Biological Evaluation of 6-Substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimi
Discovery of Piperidine-Linked Pyridine Analogues as Potent Non-nucleoside HIV-1 Reverse Transcripta
Recent Advances in the Research of 2,3-Diaryl-1,3-thiazolidin-4-one Derivatives as Potent HIV-1 Non-
Novel Piperidinylamino-diarylpyrimidine Derivatives with Dual Structural Conformations as Potent HIV
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HI
Synthesis, In Vitro and In Vivo Release Kinetics, and Anti-HIV Activity of A Sustained-Release Prodr
期刊信息
位置：