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基于三链DNA结构的0-1整数规划改进研究
  • ISSN号：1001-3695
  • 期刊名称：计算机应用研究
  • 时间：2013.1.15
  • 页码：56-59+77
  • 分类：TP301.6[自动化与计算机技术—计算机系统结构;自动化与计算机技术—计算机科学与技术]
  • 作者机构：[1]山东师范大学管理科学与工程学院,济南250014
  • 相关基金：国家自然科学基金资助项目（61170038）; 山东省自然科学基金资助项目（ZR2011FM001）; 国家教育部人文社会科学研究项目（12YJA630152）; 山东省社会科学基金资助项目（11CGLJ22）; 山东省高等学校科技计划资助项目（J12LN22,J12LN65）
  • 相关项目：基于DNA计算和离散Morse方法的聚类分析研究
作者： 任晓玲|白雪|刘希玉|
关键词： 三链DNA, 0-1整数规划, DNA计算, triple-stranded DNA, 0-1 integer programming, DNA computing
中文摘要：

为实现DNA计算中对解的有效筛选,防止探针与探针之间的错配、发夹结构等,以及便于检测最终解,提出了改进的三链DNA模型求解0-1规划的设计。该方法编码n个变量的每种组合的所有排列情况。此编码方式不仅使计算所需有效分子量从O（（2n）!）下降到O（2nn!）,并使对可行解的筛选更加有效。利用寡聚脱氧核苷酸（ODN）在RecA蛋白介导下与同源的双链DNA匹配成三螺旋DNA的特点,可推广到更多以双链DNA分子为计算模型的解的检测中。

英文摘要：

To realize the effective screening of solutions in DNA computing and to prevent the mismatch between probes,the formation of the hairpin structure etc,this paper presented an improved triple-stranded DNA model to solve 0-1 integer programming problem.This method made a full array of all combinations of n 0-1 variables.Compared with the original one,the amount of DNA strands needed dropped from O（（2n）!） to O（2nn!） and the improved one made a better selection of feasible solutions.Triple-helix structure could be constructed by the homologous double-helix DNA with the oligodeoxyribonucleotides（ODN） in the mediated of RecA protein.It could make use of its special structure to promote it to the selection of solutions with the double-helix computing model.

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期刊信息
  • 《计算机应用研究》
  • 北大核心期刊（2011版）
  • 主管单位:四川省科学技术厅
  • 主办单位:四川省计算机研究院
  • 主编：刘营
  • 地址：成都市成科西路3号
  • 邮编：610041
  • 邮箱：arocmag@163.com
  • 电话：028-85210177 85249567
  • 国际标准刊号：ISSN：1001-3695
  • 国内统一刊号：ISSN：51-1196/TP
  • 邮发代号:62-68
  • 获奖情况:
  • 第二届国家期刊奖百种重点科技期刊,国内计算技术类重点核心期刊,国内外著名数据库收录期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,波兰哥白尼索引,英国科学文摘数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:60049