中文摘要：

生命分析化学是研究与生命活动相关的化学分子检测原理与方法的新兴交叉学科领域。其中将电化学分析方法与生物芯片相结合形成的电化学生物芯片正在向集成化、通量化、微型化和自动化等方向迅速发展。本文介绍近年来电化学检测在DNA芯片、蛋白质芯片以及适配体芯片等方面有代表性的研究进展。文中阐述了高、低密度电化学DNA芯片的制备与多种伏安检测方法；讨论了多酶电极芯片结构与测定干扰之间的关系，介绍了伏安法、阻抗法等电化学方法在蛋白质芯片中的应用进展。此外，还简要介绍了电化学适配体芯片的制备及检测方法，并展望了电化学生物芯片的发展前景。

英文摘要：

Ananlytical chemistry for life science is an interdisciplinary scientific field to develop novel analytical principles, methods and techniques for detecting chemical molecules and providing scientific data and information for life science. Combining electrochemical methods with microarray technology, electrochemical biochips are being developed acceleratedly towards integration, throughput, miniaturization, automation. Recent progress in the development of electrochemical detection methods for DNA arrays and protein arrays as well as aptamer arrays are summarized in this review. In the case of electrochemical DNA arrays, numerous fabrication methods of DNA capture probes for high throughput and focused DNA arrays are presented. Electrochemical detection is focused on vohammetry by using various electrochemical probes or label-free approach. The development of arrayed electrodes immobilized with antibodies and aptamers is also discussed, in which vohammetry and electrochemical impedance measurements have been used to assay multiplexed protein targets.