尝试了用金(Au)催化吲哚和炔烃的Friedel-Crafts烷基化反应,具体探讨了金(I)配合物催化吲哚与末端炔烃的烷基化反应的条件,并制备了一系列尚未见文献报道的双取代β-吲哚烷基化衍生物.产物的结构经^1H NMR,^13C NMR,MS和元素分析确证.并对其反应机理可能性进行了推测.
An intermolecular Friedel-Crafts alkylation reaction of substituted indoles with terminal alkynes has been carried out in the presence of gold(I) complex as the catalyst. The β-bis(indol-3-yl)alkane derivatives were synthesized for the first time and identified by ^1H NMR, ^13C NMR, MS techniques and elemental analysis. A possible reaction mechanism has been suggested.