中文摘要：

目的 测定结直肠癌患者可溶性E选择素（SE-selectin）的血清水平并探讨其临床意义。方法 采用ELISA法检测84例结直肠癌患者和30名正常人血清sE-selectin水平，随访其中54例患者，比较其手术前后血清sE-selectin水平的变化，并对结直肠癌患者sE-selectin、CEA、CA199和CA242的阳性率进行比较。结果 84例结直肠癌患者血清sE-selectin阳性率为71．4％，其水平为55．21±8．98ng／ml，明显高于正常人群（17．94±5．53ng／ml，P％0．001），DukesD期患者sE-selectin水平为75．43±8．67ng／ml，显著高于A、B、C期水平（P〈0．01）；sE-selectin水平与年龄、性别、肿瘤部位及组织学分级无明显相关（P〉0．05）。13例结直肠癌肝转移患者血清sE-selectin水平明显高于无肝转移患者（P〈0．01）。结直肠癌患者术后1、12个月及12月以上血清sE-selectin水平同术前比较有显著差异（P〈0．001）。sE-selectin阳性率明显高于CEA、CA199、CA242及CEA＋CA199＋CA242联合检测的阳性率（P〈0．01）。sE-selectin水平升高组较水平正常组肿瘤患者生存率显著降低（P〈0．01）。结论 sE-selectin在结直肠癌中阳性率较高，动态检测sE-selectin水平对于预测复发转移、评估预后具有重要临床意义，血清sE-selectin可能成为结直肠癌及其肝转移有价值的标志物。

英文摘要：

Objective To study the clinical significance of the serum level of soluble E-seleetin （sE-selectin） in diagnosis and treatment of coloreetal cancer. Methods The serum level of sE-seleetin was measured by ELISA in 84 patients with coloreetal cancer and 30 normal individuals as control. The changes in serum sE-selectin level of 54 patients with colorectal cancer were analyzed preoperatively and postoperatively, and the positive ratio of sE-seleetin was compared with that of CEA, CA199 and CA242 in patients with colorectal cancer. Results The serum sE-seleetin level in coloreetal cancer was significantly higher than that of normal control （P〈0. 001）. sE-seleetin level in patients scored as Dukes＇ stage D was significantly higher than that in Dukes＇ stage A, B or C patients and healthy control （P〈0. 05）. The sE-seleetin level was not different in regard to sex, age, tumor location and degree of differentiation （P〈0. 05）. There was statistically significant difference between the patients with and without hematogenous metastasis （P〈0. 05）. The sE-selectin level at 1 month, 12 months and over 12 months postoperative showed a lower level than preoperative level （P〈0. 001）. The positive ratio of sE-seleetin was significantly higher than that of CEA, CA199 and CA242 in patients with coloreetal cancer （P〈0. 001）. The survival rate of high sE-seleetin level group was significantly lower than that of low sE-seleetin level group （P〈0. 01）. Conclusions sE-seleetin can be regarded as a novel tumor marker of coloreetal cancer, especially with hematogenous metastasis. Dynamic diagnosis, effect evaluation and prognosis judgment.