中文摘要：

肿瘤转移抑制基因KiSS-1广泛存在于人体各种组织，其表达受多种因素的调控。大量研究证明，KiSS-1基因表达的降低或突变与黑色素瘤、乳腺癌、甲状腺癌、胃癌以及膀胱癌等的浸润、转移和不良预后密切相关。KiSS-1基因在肿瘤侵袭和转移过程中的作用目前尚未完全清楚，还有待进一步研究证实。

英文摘要：

KiSS-1 gene is a metastasis suppressor gene in varieties of normal human tissues. The expression of KiSS-1 gene is regulated by various factors. Lots of researches have suggested that KiSS-1 gene is closely associated with invasion, metastases and poor prognosis of melanoma, breast cancer, thyroid cancer, gastric cancer and bladder cancer. As tumor invasion and metastasis is a complicated process, in which the function of KiSS-1 gene is not clear now, further studies need to be conducted on it.