中文摘要：

结缔组织生长因子能促进成骨细胞增殖分化，抑制成骨细胞功能，促进风湿性关节炎患者血清破骨细胞生成，刺激软骨细胞的增殖和分化，促进体内外血管生成，在骨和软骨的生长发育以及骨量维持方面起非常重要的作用。

英文摘要：

It has been demonstrated that connective tissue growth factor（CTGF） may enhance proliferation and differentiation of osteoblasts, inhibit the functions of osteoblasts, increase osteoclastogenesis in patients with Rheumatoid Arthritis, stimulate proliferation and differentiation of chondrocytes, and induce angiogenesis in vivo and vitro. Above all, CTGF plays an important role in sustaining growth of skeleton and cartilage, and thus maintaining bone quantity.