中文摘要：

目的探讨IL-17、IL-10及TGF-β在慢性丙型肝炎发病中的作用，观察聚乙二醇旺干扰素抗病毒治疗对上述细胞因子水平的影响。方法采用ELISA法检测20例慢性丙型肝炎患者在聚乙二醇α干扰素治疗前后IL-17、IL-10和TGF-β的水平。结果慢性丙型肝炎患者IL-17和IL-10的水平均显著高于正常对照组（P〈0．001），TGF-β水平在两组间无显著性差异。抗病毒治疗后，慢性丙型肝炎患者血清IL-17和IL-10的水平均较治疗前显著性下降（P〈0．001）。结论IL-17和IL-10共同参与了慢性丙型肝炎的发病，此结论对预测抗病毒疗效有指导意义。

英文摘要：

Objective To study the expression of serum IL-17,IL-10 and TGF-β in patients with chronic hepatitis C,and to investigate the changes of the three eytokines after treatment of PEG-IFNα. Methods The serum levels of IL-17,IL-10 and TGF-β in 20 patients with chronic hepatitis C before and after treatment of PEG-IFNα were determined by ELISA. Results The serum levels of IL-17, IL-10 and TGF-βin patients with chronic hepatitis C were significant higher than those in normal controls （ P 〈 0. 001 ）, the levels of IL-17, and IL-10 decreased obviously（ P 〈 0. 001 ） in responsive patients after treatment.-Conclu- sion IL-17 and IL-10 may participate in the pathogenesis of chronic hepatitis C and may be correlation with histological inflammation. The important clinical significance is showed in judging the result of antiviral treatment.